M&A in pharma
Explores the merits of mega-deal in contrast to a more measured portfolio growth strategy
Antiageing and Life Enhancement Pharmacotherapeutics
| Publication Date | January 2006 |
| ISBN | n/a |
| Pages | 580 |
| Tables | 127 |
| Figures | 53 |
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Antiageing and life enhancement therapy areas are poised for dramatic expansion over the next decade driven by factors such as increasing worldwide ageing populations, unrelenting media fixation on physical improvement and restorative antiageing treatments, and innovation in the pharmaceutical industry to bring to market highly sophisticated efficacious drug treatments that serve to close the gap between medical and cosmetic interventions. Research and development investment in the specialty area is unfaltering with over 180 companies collectively investing more than US$5 billion in the hope to capitalize on a dynamic pipeline of 275 drug candidates that are currently progressing through to the clinic. Although the capital risks are high in the antiageing and life enhacement R&D arena, the potential returns on investment are vast in a market currently estimated at US$36 billion and predicted to rise to US$49 billion by 2012, and over US$100 billion by 2020.
New drug indications combined with next generation molecules and compounds will transform the landscape of how physicians treat disorders associated with ageing or lifestyle. Current drugs are being developed with multiple therapeutic benefits that will be able to treat several ailments through single dosing. Drugs on the horizon indicated for obesity, for example, also display secondary benefits for patients with coexisting diabetes and dyslipidaemia in addition to crossover indications for tobacco addiction. In this instance the interrelation of metabolic diseases can be improved by one drug alone as opposed to three potential drug medications, a facet that will revolutionize drug treatment regimens for patients, particularly those with high cardiovascular disease risk profiles where coexisting obesity, diabetes and smoking increase disease susceptibility. Moreover, novel drugs that alter body composition or effect changes in functional aspects of daily living are anticipated to not only change the armamentarium of medical treatments in the antiageing domain but also alter the ©2006 Spectra Intelligence. All rights reserved.
medical perceptions of antiageing and life-enhancement treatments. Novel pharmacotherapeutics may redefine treatment paradigms allowing physicians the capacity to impede or rejuvenate internal physiological ageing mechanisms or halt deleterious effects caused by lifestyle activities. Pharmacological innovation in the field may even prove beneficial in the prevention of illnesses associated with traditional drug development areas, such as in musculoskeletal disease, cancer and neurodegenerative diseases due to therapeutic synergies and shared drug targets that underly salient pathophysiological mechanisms. In short, the antiageing and life enhancement specialty area is evolving into an exciting, innovative and highly dynamic discipline. Based on current trends, it is expected that the therapy areas will flourish offering a myriad of new drug treatment options for a range of conditions that are currently poorly served with high unmet needs.
In this report entitled Antiageing and Life Enhancement Pharmacotherapeutics:
Rejuvenating Drug Markets to 2012 and Beyond, the reader will be introduced to a specialty pharmaceutical market that is transitioning to a high-growth, high-value prospect. The scope of the report encompasses up-to-date coverage of epidemiological, aetiological, and demographic data related to ageing and lifestyle disorders. Furthermore, market insights are provided by way of extensive sector analyses of marketed and newly launched products, pipeline drugs, and companyactivities, in addition to comment on strategic and commercial issues that may affect product positioning and revenue optimization. The report also discusses key prospects that have the potential to create new market sectors and become blockbuster products over the next decade.
Chapter 1 provides an overview of the antiageing and life enhancement domain and outlines the extent of the therapy areas and how they are categorized, classified, and characterized. This chapter also provides a comprehensive account of prevalence statistics, pathophysiology, treatment methods, and the types of pharmacotherapies currently available to combat symptoms of ageing and impairments that are related to lifestyle dysfunction.
An in-depth evaluation of dermatological conditions related to ageing and lifestyle is presented in Chapter 2. Therapy areas include alopecia, cutaneous ageing, pigmentation disorders, and the lipodermal areas of obesity and lipodystrophy. The chapter provides a detailed analysis of the sector to include insights for product extension and optimization, sales forecasts to 2012, and impact of late-stage pipeline ©2006 Spectra Intelligence. All rights reserved. drugs on the market. Each therapy area segment concludes with a summary of the key issues that are considered to affect growth and sustainability.
Report Highlights And Key Findings
- Data-intensive multipart tome on the state of the US$36bn antiageing and life enhancement drug market
- In-depth market research and analysis of over 15 market sectors and subsectors
- Comprehensive review of epidemiological, aetiological and therapeutic data for over 40 disorders
- Sales estimates (US$) to 2012 for over 90 key products
- Therapy forecasting for 10 specialty areas (US$)
- Strategic insights for life-cycle optimization and product development
- Evaluation of leading products and major competitors
- Identified emerging growth markets with high-revenue yielding prospects
- Recognized market drivers and inhibitors in the specialty pharma sector
- Trend analysis of industry events and activities over the past 2 years
- Detailed R&D themes and clusters by therapy area
- Data generation on sector and market values between 2004-2012 and predictions to 2020 (US$)
Reasons To Purchase This Report
- Qualitative assessment of current disorder characteristics, definitions, including aetiological and epidemiological data
- Comprehensive update on antiageing and life enhancement drugs sector
- In-depth analysis and discussion on the pathophysiology and prevalence of the main ageing and lifestyle disorders, including alopecia, cutaneous ageing, pigmentations conditions, obesity, depressive illnesses, addictions, sleep disorders, cognitive and memory impairments, contraception, infertility, and sexual disorders
- Provides unrivalled insight into the development of antiageing and life enhancement drugs and emerging market opportunities
- Market value predictions by therapy area and for individual marketed products to 2012
- Quantitative analysis of marketed drugs and impact of new close-to-market candidates and pipeline products
- Insight into potential blockbusters and super-blockbusters of the future
- Illustrates the importance and need for antiageing and lifestyle medicines over the next 20 years
- Provides extensive coverage of R&D pipelines of key players in the sector
- Shows proprietary market modelling for prospect analysis across 15 main therapy areas.
What Can Be Learnt From This Report?
- How are antiageing and lifestyle conditions defined and characterized?
- What are the therapeutic benefits of antiageing and lifestyle drugs?
- What are the main areas of antiageing and lifestyle drug development?
- What criteria are involved in creating blockbuster antiageing and life enhancement drugs?
- What is the impact of global ageing in lifestyle drug development?
- What are the prevalence rates of ageing conditions and lifestyle disorders globally?
- What factors are shaping the future of antiageing and lifestyle drug drug development?
- What are the current market values for antiageing and life enhancement drugs and what will be the market value of this sector by 2012?
- What are the emerging market opportunities for antiageing drugs?
- What are the emerging market opportunities for life enhancement drugs?
- Which therapeutic areas are identified for high-value growth?
- Who are the main players in the antiageing and life enhancement domain?
- Which companies are developing antiageing and life enhancement drugs?
- Which antiageing and lifestyle drug development therapeutic areas are research intensive and which are not?
- Which therapy areas are saturated and which represent niche market opportunities?
- What is the future outlook for marketed antiageing and lifestyle drugs and for those in development?
- What is the prediction for the global markets by 2020?
- What are the top prospects in the development pipeline for antiageing and life enhancement therapy sectors?
Chapter 1 Introduction to Antiageing and Life Enhancement Pharmacotherapeutics
Ageing and Life Enhancement
What are Antiageing and Life Enhancement Pharmacotherapeutics?
Classifying the Ageing and Lifestyle Conditions
Characteristics of Ageing and Lifestyle Conditions
Categorizing Ageing and Lifestyle Conditions
Marketed Antiageing and Life Enhancement Drugs
Ageing, Lifestyle Conditions, and Dermatology
Alopecia
Prevalence of Alopecia
Alopecia as a Lifestyle Problem
The Normal Hair Growth Cycle
Types of Alopecia
Dermal Ageing
Photodamage and Solar Radiation
Pollution and Dermal Damage
Dermal Pigmentation
Hyerpigmentation and Hypopigmentation Disorders
Biological Basis to Pigmentation: Melanogenesis and Photoprotection
Cellular Mechanisms of Melanogenesis and Photoprotection
Hyperpigmentation Disorders
Hypopigmentation Disorders
Vitiligo
Albinism
Postinflammatory Hypopigmentation
Lipodermal Disorders
Gynoid Lipodystrophy
The Development of Cellulite
Treatments Options for Cellulite
Obesity
Obesity Prevalence
Types of Obesity
Measuring and Diagnosing Obesity
Aetiological Aspects of Obesity
Physiological Aspects of Hunger and Satiety
Health Risks of Obesity
Psychosocial Aspects of Obesity
Ageing, Life Enhancement, and the Central Nervous System
Depression
Prevalence
Aetiology of Depression
Types of Depression
Major depression
Dysthymia
Bipolar Disorder
Symptoms of Depression
Anxiety Disorders
Prevalence
Addiction Disorders
Incidence of Addiction Disorders
Neurobiological Basis of Addiction
Treatment Options
Cognitive/Memory Deficits
Prevalence
Pharmacotherapy for Cognitive Impairment
Sleep Disorders
Insomnia
Prevalence of Insomnia
Causes of Insomnia
Restless Legs Syndrome
Prevalence of Restless Legs Syndrome
Circadian Rhythm Sleep Disorders
Delayed Sleep Disorders
Shift-Work Sleep Disorder
Jet-Lag Sleep Disorders
Excessive Daytime Sleepiness and Narcolepsy
Narcolepsy
Prevalence of Narcolepsy
Neurobiological Basis to Narcolepsy
Treatments for Narcolepsy
Sleep Apnoea
Obstructive Sleep Apnoea
Prevalence of Obstructive Sleep Apnoea
Therapeutics for Sleep Apnoea
Ageing, Lifestyle Conditions, and Reproductive Health
Elective Infertility - Contraception
The Birth of Contraception
Inducing Infertility via Ovulation Suppression
Combined Oral Contraceptives
Fertility Disorders
Assisted Conception
Ageing, Lifestyle Conditions, and Urology
Sexual Disorders
Prevalence of Sexual Dysfunction
Male Sexual Disorders
Sexual Desire Disorders
Male Erectile Dysfunction
Normal Erectile Function
Psychological Aspects of Male Erectile Dysfunction
Prevalence of Male Erectile Dysfunction
Therapeutics for Male Erectile Dysfunction
Priapism
Peyronie's disease
Disorders of Ejaculation
Premature Ejaculation
Retarded Ejaculation
Retrograde Ejaculation
Female Sexual Dysfunction
Prevalence of Female Sexual Dysfunction
Specific Female Sexual Dysfunction Disorders
Disorders of Desire
Disorders of Arousal
Disorders of Lubrication
Persistent Sexual Arousal Syndrome
Disorders of Orgasm
Pain Disorders
Dyspareunia
Vulvodynia
Vaginismus
What are Antiageing and Life Enhancement Pharmacotherapeutics?
Classifying the Ageing and Lifestyle Conditions
Characteristics of Ageing and Lifestyle Conditions
Categorizing Ageing and Lifestyle Conditions
Marketed Antiageing and Life Enhancement Drugs
Ageing, Lifestyle Conditions, and Dermatology
Alopecia
Prevalence of Alopecia
Alopecia as a Lifestyle Problem
The Normal Hair Growth Cycle
Types of Alopecia
Dermal Ageing
Photodamage and Solar Radiation
Pollution and Dermal Damage
Dermal Pigmentation
Hyerpigmentation and Hypopigmentation Disorders
Biological Basis to Pigmentation: Melanogenesis and Photoprotection
Cellular Mechanisms of Melanogenesis and Photoprotection
Hyperpigmentation Disorders
Hypopigmentation Disorders
Vitiligo
Albinism
Postinflammatory Hypopigmentation
Lipodermal Disorders
Gynoid Lipodystrophy
The Development of Cellulite
Treatments Options for Cellulite
Obesity
Obesity Prevalence
Types of Obesity
Measuring and Diagnosing Obesity
Aetiological Aspects of Obesity
Physiological Aspects of Hunger and Satiety
Health Risks of Obesity
Psychosocial Aspects of Obesity
Ageing, Life Enhancement, and the Central Nervous System
Depression
Prevalence
Aetiology of Depression
Types of Depression
Major depression
Dysthymia
Bipolar Disorder
Symptoms of Depression
Anxiety Disorders
Prevalence
Addiction Disorders
Incidence of Addiction Disorders
Neurobiological Basis of Addiction
Treatment Options
Cognitive/Memory Deficits
Prevalence
Pharmacotherapy for Cognitive Impairment
Sleep Disorders
Insomnia
Prevalence of Insomnia
Causes of Insomnia
Restless Legs Syndrome
Prevalence of Restless Legs Syndrome
Circadian Rhythm Sleep Disorders
Delayed Sleep Disorders
Shift-Work Sleep Disorder
Jet-Lag Sleep Disorders
Excessive Daytime Sleepiness and Narcolepsy
Narcolepsy
Prevalence of Narcolepsy
Neurobiological Basis to Narcolepsy
Treatments for Narcolepsy
Sleep Apnoea
Obstructive Sleep Apnoea
Prevalence of Obstructive Sleep Apnoea
Therapeutics for Sleep Apnoea
Ageing, Lifestyle Conditions, and Reproductive Health
Elective Infertility - Contraception
The Birth of Contraception
Inducing Infertility via Ovulation Suppression
Combined Oral Contraceptives
Fertility Disorders
Assisted Conception
Ageing, Lifestyle Conditions, and Urology
Sexual Disorders
Prevalence of Sexual Dysfunction
Male Sexual Disorders
Sexual Desire Disorders
Male Erectile Dysfunction
Normal Erectile Function
Psychological Aspects of Male Erectile Dysfunction
Prevalence of Male Erectile Dysfunction
Therapeutics for Male Erectile Dysfunction
Priapism
Peyronie's disease
Disorders of Ejaculation
Premature Ejaculation
Retarded Ejaculation
Retrograde Ejaculation
Female Sexual Dysfunction
Prevalence of Female Sexual Dysfunction
Specific Female Sexual Dysfunction Disorders
Disorders of Desire
Disorders of Arousal
Disorders of Lubrication
Persistent Sexual Arousal Syndrome
Disorders of Orgasm
Pain Disorders
Dyspareunia
Vulvodynia
Vaginismus
Chapter 2 Dermatology
Alopecia
Alopecia Drug Market Overview
Market Forecasts for Alopecia Products
Market Analysis for the Alopecia Drug Market
Propecia (Finasteride) - Merck
Rogaine/Regaine (Minoxidil) - Pfizer
Product Extension Strategy Insights for Alopecia Products
Product Extension Strategy Insights for Finasteride
Product Extension Strategy Insights for Minoxidil
Future Considerations for Drugs to Treat Alopecia
Drug Development Prospects
BIO024 - Genaderm
Other Clinical Candidates
Cutaneous Ageing
Dermal Ageing Product Market Overview
Market Forecasts for Dermal Ageing Products
Market Analysis for Cutaneous Ageing/Photodamage Products
Market Insights and Strategies for the Botulinum Toxin Sector
Direct Competition to Botox
Botulinum Toxin Products in Asia and South America
Product Extension Strategy Insights for Botulinum Toxin Products
Market Insights and Strategies for the Topical Antiageing Product Sector
Product Extension Strategy Insights for Topical Antiageing Products
Tretinoin
Isotretinoin
Tazarotene
Idebenone
Acid Peel Products
Future Considerations and Market Insights for the Cutaneous Antiageing
Product Sector
Dermal Pigmentation Conditions
Market Forecasts for Dermal Pigmentation Products
Market Analysis of the Dermal Pigmentation Product Sector
Market Insights and Potential Product Development Strategies for Hyperpigmentation
Conditions
Hydroquinone
Tretinoin
Azelaic Acid
Market Insights and Potential Product Development Strategies for Hypopigmentation
Conditions
Induced Photoprotective Melanogenesis
Therapeutic, Prophylactic, and Cosmetic Markets for Photoprotective Melanogenesis
Solar Allergies/Polymorphous Light Eruption
Other Hypopigmentation Conditions
Skin Cancer Prophylaxis
Cosmetic-Medical Indications
Future Considerations and Market Outlook for the Dermal Pigmentation Therapy Area
Lipodermal Conditions
Gynoid Lipodystrophy (Cellulite)
Novel Pharmacotherapeutics for Cellulite
BIO303 - Enhance Biotech/Bioaccelerate
Phosphatidylcholine (Lecithin)
Redeveloping Old Molecules for New Cosmetic Indications
Obesity
Market Analysis for Antiobesity Drugs
Market Forecasts for Antiobesity Drugs
Antiobesity Product Extension Strategies and Insights
Sibutramine - (Meridia/Reductil) Abbot Laboratories
Market Outlook for Sibutramine
Orlistat
Class Competition - ATL-962 (Cetilistat) Alizyme
Product Extension Strategy Insights for Orlistat
Antiobesity Drugs at the Premarket Authorization Stage
Rimonabant
Safety and Efficacy Data
Lipodermal Disorders - Future Considerations and Market Insights
New Weight Regulation and Lipid Metabolism Market Opportunities
Alopecia Drug Market Overview
Market Forecasts for Alopecia Products
Market Analysis for the Alopecia Drug Market
Propecia (Finasteride) - Merck
Rogaine/Regaine (Minoxidil) - Pfizer
Product Extension Strategy Insights for Alopecia Products
Product Extension Strategy Insights for Finasteride
Product Extension Strategy Insights for Minoxidil
Future Considerations for Drugs to Treat Alopecia
Drug Development Prospects
BIO024 - Genaderm
Other Clinical Candidates
Cutaneous Ageing
Dermal Ageing Product Market Overview
Market Forecasts for Dermal Ageing Products
Market Analysis for Cutaneous Ageing/Photodamage Products
Market Insights and Strategies for the Botulinum Toxin Sector
Direct Competition to Botox
Botulinum Toxin Products in Asia and South America
Product Extension Strategy Insights for Botulinum Toxin Products
Market Insights and Strategies for the Topical Antiageing Product Sector
Product Extension Strategy Insights for Topical Antiageing Products
Tretinoin
Isotretinoin
Tazarotene
Idebenone
Acid Peel Products
Future Considerations and Market Insights for the Cutaneous Antiageing
Product Sector
Dermal Pigmentation Conditions
Market Forecasts for Dermal Pigmentation Products
Market Analysis of the Dermal Pigmentation Product Sector
Market Insights and Potential Product Development Strategies for Hyperpigmentation
Conditions
Hydroquinone
Tretinoin
Azelaic Acid
Market Insights and Potential Product Development Strategies for Hypopigmentation
Conditions
Induced Photoprotective Melanogenesis
Therapeutic, Prophylactic, and Cosmetic Markets for Photoprotective Melanogenesis
Solar Allergies/Polymorphous Light Eruption
Other Hypopigmentation Conditions
Skin Cancer Prophylaxis
Cosmetic-Medical Indications
Future Considerations and Market Outlook for the Dermal Pigmentation Therapy Area
Lipodermal Conditions
Gynoid Lipodystrophy (Cellulite)
Novel Pharmacotherapeutics for Cellulite
BIO303 - Enhance Biotech/Bioaccelerate
Phosphatidylcholine (Lecithin)
Redeveloping Old Molecules for New Cosmetic Indications
Obesity
Market Analysis for Antiobesity Drugs
Market Forecasts for Antiobesity Drugs
Antiobesity Product Extension Strategies and Insights
Sibutramine - (Meridia/Reductil) Abbot Laboratories
Market Outlook for Sibutramine
Orlistat
Class Competition - ATL-962 (Cetilistat) Alizyme
Product Extension Strategy Insights for Orlistat
Antiobesity Drugs at the Premarket Authorization Stage
Rimonabant
Safety and Efficacy Data
Lipodermal Disorders - Future Considerations and Market Insights
New Weight Regulation and Lipid Metabolism Market Opportunities
Chapter 3 Central Nervous System/Psychiatry
Psychological Disorders: Depression and Anxiety
Market Overview of Drugs to Treat Depression and Anxiety Disorders
Market Analysis and Insights for Drugs to Treat Depressive Illnesses
Market Analysis: Antidepressant Therapy Area
Prozac (Fluoxetine) - Eli Lilly
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Cymbalta (Duloxetine) - Eli Lilly/Boehringer Ingelheim
Product Overview
Indications and Supplementary Labelling
Sales Prospects
Commercial Outlook
Zoloft/Lustral (Sertraline) - Pfizer
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Seroxat/Paxil/Deroxat (Paroxetine) - GlaxoSmithKline
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Wellbutrin (Bupropion) - GlaxoSmithKline
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Effexor (Venlafaxine) - Wyeth
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Remeron/Zispin (Mirtazapine) - Organon/Akzo Nobel
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Cipramil/Celexa (Citalopram) - Lundbeck/Forest Laboratories
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Cipralex/Lexapro (Escitalopram) - Lundbeck/Forest
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Future Considerations and Market Insights for the Antidepressant Market
Pipeline Antidepressants
Pipeline Focus
Valdoxan (Agomelatine) - Servier
Pharmacotherapeutics for Cognitive/Memory Deficits
Future Market Focus - Age-Related Cognitive Decline
Companies Developing Drugs for Memory and Cognitive Enhancement
Behavioural Disorders: Addictions
Market Overview for Addiction Disorders
Market Forecasts by Therapeutic Area
Alcohol Addiction
Narcotic Addiction
Tobacco Addiction
Market Forecasts for Addiction Disorders
Market Analysis of Drugs to Treat Addiction Disorders
Alcohol Addiction
Alcohol Addiction Pharmacotherapies
Acamprosate (Campral) - Merck/Forest Laboratories
Mechanisms of Action/Efficacy
Sales Estimates for Campral
Product Line Extension Possibilities
Disulfiram (Antabuse) - Alpharma
Mechanism of Action/Efficacy
Sales Estimates for Disulfiram
Naltrexone Hydrochlride
Mechanisms of Action/Efficacy
Reformulation - Vivitrol, Alkermes/Cephalon
Sales Estimates for Naltrexone
Pipeline Focus
Naltrexone Depot - Drug Abuse Sciences, France
Nalmefene - BioTie Therapies, Finland
Alcohol Addiction - Market Insights and Future Considerations
Narcotic Addiction Pharmacotherapeutics
Cocaine Addiction
Mechanisms of Action of Cocaine
Future Therapeutics for Cocaine Addiction
Vaccine Therapy Focus - Xenova
COC-AB/DAS-431 - Drug Abuse Sciences
Opiate Addiction
Drug Substitute Therapies
Subutex/Subroxone (Buprenorphine) - Schering-Plough/Reckitt Benckiser
Mechanisms of Action/Efficacy
Reformulation
Sales Estimates
Methadone
Mechanisms of Action/Efficacy
Sales Estimates
Drugs to Control Opiate Withdrawal Symptoms
Brittofex (Lofexidine) - Britannia Pharmaceuticals
Mechanisms of Action/Efficacy
Sales Estimates
Naltrexone
Potential Reformulation
Future Drugs to Treat Opiate Addiction
Probuphine - Titan Pharmaceuticals
Buprenorphine Depot - Drug Abuse Sciences
Narcotic Addiction - Market Insights and Future Considerations
Emerging Drug Addiction Focus
Methamphetamine/Phencyclidine Abuse and Dependency
InterveXion Therapeutics
Outlook for Pharmacotherapeutic Markets Related to Alcohol and
Substance Abuse
Smoking Addiction
Prevalence and Mortality Statistics
Nicotine - Mechanism of Action
Nicotine Dependency and Smoking Cessation
Smoking and Health Consequences
Healthcare Costs of Smoking Addiction
Smoking Addiction Pharmacotherapeutics
Market Analysis of Smoking Cessation Pharmacotherapeutics
Nicotine Replacement Therapies
Nicorette/Nicotrol - Pfizer
Sales Estimates
NiQuitin/NicoDerm/Nicorette/Nicabate - GlaxoSmithKline
Sales Estimates
Nicotinell/Habitrol - Novartis
Sales Estimates
Other Smoking Cessation Pharmacotherapies
Zyban (Bupropion) - GlaxoSmithKline
Sales Estimates
Future Drugs to Treat Smoking Addiction
Late-Stage Development Product Focus
Rimonabant (Acomplia) - Sanofi-Aventis
Varenicline - Pfizer
Vaccine Focus
NicVAX - Nabi Biopharmaceuticals
TA-NIC - Xenova
Smoking Addiction - Market Insights and Future Considerations
Drugs in the Pipe
Behavioural/CNS: Sleep Disorders
Market Overview for Sleep Disorders
Insomnia
Wake-Promotion
Restless Legs Syndrome
Market Analysis for Drugs to Treat Sleep Disorders
Insomnia
Market Analysis for the Insomnia Pharmacotherapies
Key Insomnia Drugs
Ambien/Stilnox/Stilnoct/Myslee (Zolpidem) - Sanofi-Aventis
Mechanism of Action
Efficacy
Reformulation
Sales Estimates
Commercial Outlook
Halcion (Triazolam) - Pfizer
Mechanism of Action
Reformulation
Sales Estimates
Commercial Outlook
Lunesta (Eszopiclone) - Sepracor
Mechanism of Action
Sales Estimates
Commercial Outlook
Rozerem (Ramelteon) - Takeda Pharmaceuticals
Mechanism of Action
Efficacy
Sales Estimates
Commercial Outlook
Sonata (Zaleplon) - Wyeth/King Pharmaceuticals
Mechanism of Action
Efficacy
Reformulation
Sales Estimates
Commercial Outlook
Premarket Focus - Late-Stage Development Drugs for Insomnia
Indiplon - Neurocrine Biosciences/Pfizer
Mechanisms of Action
Formulation Development
Efficacy
Commercial Prospects
Gaboxadol - Lundbeck/Merck & Co
Mechanisms of Action
Efficacy
Commercial Prospects
Other Pipeline Drug Candidates for Insomnia
Silenor (Doxepin) - Somaxon Pharmaceuticals
Posidorm - Alliance Pharma
Future Considerations and Market Outlook for the Insomnia Drug Market
Wake-Promotion
Narcolepsy/Excessive Daytime Sleepiness
Market Analysis for Key Drugs for Narcolepy/Excessive Daytime Sleepiness
Provigil (Modafanil) - Cephalon
Mechanism of Action
Efficacy
Supplementary Indications
Reformulation
Sales Estimates
Commercial Prospects
Xyrem (Sodium oxybate) - Orphan Medical/Jazz Pharmaceuticals
Efficacy
Side Effects
Sales Estimates
Commerical Prospects
Future Considerations and Market Outlook for Wake-Promoting Drugs
Restless Legs Syndrome
Requip/Adartrel/Repreve (Ropinirole) - GlaxoSmithKline
Mechanisms of Action
Efficacy
Sales Estimates
Commercial Outlook
Drugs in Development for Restless Legs Syndrome
Premarket Focus: Pramipexole - Boehringer Ingelheim
Efficacy
Commerical Prospects
Sleep Apnoea - An Emerging High-Growth Sector
Obstructive Sleep Apnoea-Hyponoea Syndrome - An Underdiagnosed
Problem
Commercial Insights
Pipeline Focus
Future Considerations and Market Insights for Drugs to Treat Sleep
Disorders
Market Overview of Drugs to Treat Depression and Anxiety Disorders
Market Analysis and Insights for Drugs to Treat Depressive Illnesses
Market Analysis: Antidepressant Therapy Area
Prozac (Fluoxetine) - Eli Lilly
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Cymbalta (Duloxetine) - Eli Lilly/Boehringer Ingelheim
Product Overview
Indications and Supplementary Labelling
Sales Prospects
Commercial Outlook
Zoloft/Lustral (Sertraline) - Pfizer
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Seroxat/Paxil/Deroxat (Paroxetine) - GlaxoSmithKline
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Wellbutrin (Bupropion) - GlaxoSmithKline
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Effexor (Venlafaxine) - Wyeth
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Remeron/Zispin (Mirtazapine) - Organon/Akzo Nobel
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Cipramil/Celexa (Citalopram) - Lundbeck/Forest Laboratories
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Cipralex/Lexapro (Escitalopram) - Lundbeck/Forest
Product Overview
Indications and Supplementary Labelling
Patent Expiry and Reformulation
Sales Prospects
Commercial Outlook
Future Considerations and Market Insights for the Antidepressant Market
Pipeline Antidepressants
Pipeline Focus
Valdoxan (Agomelatine) - Servier
Pharmacotherapeutics for Cognitive/Memory Deficits
Future Market Focus - Age-Related Cognitive Decline
Companies Developing Drugs for Memory and Cognitive Enhancement
Behavioural Disorders: Addictions
Market Overview for Addiction Disorders
Market Forecasts by Therapeutic Area
Alcohol Addiction
Narcotic Addiction
Tobacco Addiction
Market Forecasts for Addiction Disorders
Market Analysis of Drugs to Treat Addiction Disorders
Alcohol Addiction
Alcohol Addiction Pharmacotherapies
Acamprosate (Campral) - Merck/Forest Laboratories
Mechanisms of Action/Efficacy
Sales Estimates for Campral
Product Line Extension Possibilities
Disulfiram (Antabuse) - Alpharma
Mechanism of Action/Efficacy
Sales Estimates for Disulfiram
Naltrexone Hydrochlride
Mechanisms of Action/Efficacy
Reformulation - Vivitrol, Alkermes/Cephalon
Sales Estimates for Naltrexone
Pipeline Focus
Naltrexone Depot - Drug Abuse Sciences, France
Nalmefene - BioTie Therapies, Finland
Alcohol Addiction - Market Insights and Future Considerations
Narcotic Addiction Pharmacotherapeutics
Cocaine Addiction
Mechanisms of Action of Cocaine
Future Therapeutics for Cocaine Addiction
Vaccine Therapy Focus - Xenova
COC-AB/DAS-431 - Drug Abuse Sciences
Opiate Addiction
Drug Substitute Therapies
Subutex/Subroxone (Buprenorphine) - Schering-Plough/Reckitt Benckiser
Mechanisms of Action/Efficacy
Reformulation
Sales Estimates
Methadone
Mechanisms of Action/Efficacy
Sales Estimates
Drugs to Control Opiate Withdrawal Symptoms
Brittofex (Lofexidine) - Britannia Pharmaceuticals
Mechanisms of Action/Efficacy
Sales Estimates
Naltrexone
Potential Reformulation
Future Drugs to Treat Opiate Addiction
Probuphine - Titan Pharmaceuticals
Buprenorphine Depot - Drug Abuse Sciences
Narcotic Addiction - Market Insights and Future Considerations
Emerging Drug Addiction Focus
Methamphetamine/Phencyclidine Abuse and Dependency
InterveXion Therapeutics
Outlook for Pharmacotherapeutic Markets Related to Alcohol and
Substance Abuse
Smoking Addiction
Prevalence and Mortality Statistics
Nicotine - Mechanism of Action
Nicotine Dependency and Smoking Cessation
Smoking and Health Consequences
Healthcare Costs of Smoking Addiction
Smoking Addiction Pharmacotherapeutics
Market Analysis of Smoking Cessation Pharmacotherapeutics
Nicotine Replacement Therapies
Nicorette/Nicotrol - Pfizer
Sales Estimates
NiQuitin/NicoDerm/Nicorette/Nicabate - GlaxoSmithKline
Sales Estimates
Nicotinell/Habitrol - Novartis
Sales Estimates
Other Smoking Cessation Pharmacotherapies
Zyban (Bupropion) - GlaxoSmithKline
Sales Estimates
Future Drugs to Treat Smoking Addiction
Late-Stage Development Product Focus
Rimonabant (Acomplia) - Sanofi-Aventis
Varenicline - Pfizer
Vaccine Focus
NicVAX - Nabi Biopharmaceuticals
TA-NIC - Xenova
Smoking Addiction - Market Insights and Future Considerations
Drugs in the Pipe
Behavioural/CNS: Sleep Disorders
Market Overview for Sleep Disorders
Insomnia
Wake-Promotion
Restless Legs Syndrome
Market Analysis for Drugs to Treat Sleep Disorders
Insomnia
Market Analysis for the Insomnia Pharmacotherapies
Key Insomnia Drugs
Ambien/Stilnox/Stilnoct/Myslee (Zolpidem) - Sanofi-Aventis
Mechanism of Action
Efficacy
Reformulation
Sales Estimates
Commercial Outlook
Halcion (Triazolam) - Pfizer
Mechanism of Action
Reformulation
Sales Estimates
Commercial Outlook
Lunesta (Eszopiclone) - Sepracor
Mechanism of Action
Sales Estimates
Commercial Outlook
Rozerem (Ramelteon) - Takeda Pharmaceuticals
Mechanism of Action
Efficacy
Sales Estimates
Commercial Outlook
Sonata (Zaleplon) - Wyeth/King Pharmaceuticals
Mechanism of Action
Efficacy
Reformulation
Sales Estimates
Commercial Outlook
Premarket Focus - Late-Stage Development Drugs for Insomnia
Indiplon - Neurocrine Biosciences/Pfizer
Mechanisms of Action
Formulation Development
Efficacy
Commercial Prospects
Gaboxadol - Lundbeck/Merck & Co
Mechanisms of Action
Efficacy
Commercial Prospects
Other Pipeline Drug Candidates for Insomnia
Silenor (Doxepin) - Somaxon Pharmaceuticals
Posidorm - Alliance Pharma
Future Considerations and Market Outlook for the Insomnia Drug Market
Wake-Promotion
Narcolepsy/Excessive Daytime Sleepiness
Market Analysis for Key Drugs for Narcolepy/Excessive Daytime Sleepiness
Provigil (Modafanil) - Cephalon
Mechanism of Action
Efficacy
Supplementary Indications
Reformulation
Sales Estimates
Commercial Prospects
Xyrem (Sodium oxybate) - Orphan Medical/Jazz Pharmaceuticals
Efficacy
Side Effects
Sales Estimates
Commerical Prospects
Future Considerations and Market Outlook for Wake-Promoting Drugs
Restless Legs Syndrome
Requip/Adartrel/Repreve (Ropinirole) - GlaxoSmithKline
Mechanisms of Action
Efficacy
Sales Estimates
Commercial Outlook
Drugs in Development for Restless Legs Syndrome
Premarket Focus: Pramipexole - Boehringer Ingelheim
Efficacy
Commerical Prospects
Sleep Apnoea - An Emerging High-Growth Sector
Obstructive Sleep Apnoea-Hyponoea Syndrome - An Underdiagnosed
Problem
Commercial Insights
Pipeline Focus
Future Considerations and Market Insights for Drugs to Treat Sleep
Disorders
Chapter 4 Reproductive Health: Contraception and Infertility
Reproductive Health Market Overview
Market Analysis for Contraception and Infertility
Infertility
Hormonal Contraception
Contraceptive Formulations
Combined Oestrogen-Progestogen Contraceptives
Progestogen-Only Contraceptives
Product Market for Hormonal Contraceptives
Janssen-Cilag/Ortho-McNeil/Johnson & Johnson
Key Product and Portfolio Review
Sales Estimates and Product Market Outlook
Organon/Akzo Nobel
Key Product and Portfolio Review
Pipeline Focus
EMM 310066
Male Contraception - Organon/Schering
Sales Estimates and Product Market Outlook
Pharmacia/Pfizer
Market Analysis for Contraception and Infertility
Infertility
Hormonal Contraception
Contraceptive Formulations
Combined Oestrogen-Progestogen Contraceptives
Progestogen-Only Contraceptives
Product Market for Hormonal Contraceptives
Janssen-Cilag/Ortho-McNeil/Johnson & Johnson
Key Product and Portfolio Review
Sales Estimates and Product Market Outlook
Organon/Akzo Nobel
Key Product and Portfolio Review
Pipeline Focus
EMM 310066
Male Contraception - Organon/Schering
Sales Estimates and Product Market Outlook
Pharmacia/Pfizer