Handbook of Pharmaceutical Additives

3rd Edition

Publication Date April 2007
ISBN 978-1-890595-93-7
Pages 1200
Tables n/a
Figures n/a

Print £275 $435

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More than 5,300 trade name products and 4,000 generic chemicals and materials...

Newly Updated

The Handbook of Pharmaceutical Additives, 3rd Edition describes more than 5,300 trade name products and 4,000 generic chemicals and materials, available from worldwide manufacturers, that function as pharmaceutical additives. Pharmaceutical additives are defined in this reference as secondary ingredients present in both prescription and over-the-counter drug formulations and contributing in one or more of the following ways:

  • Improving consumption ease of the dosage form by masking unpleasant odor, improving palatibility or appearance of the active ingredient.
  • Enabling or enhancing the delivery of the drug or medicine that is available in a variety of dosage forms (i.e., oral; topical, ophthalmic, and otic; suppositories; injectables; inhalants) and thus improving its efficacy, control of bioavailability, uniformity, and/or flow characteristics
  • Increasing the stability of active ingredients
  • Acting as a filler or diluent so that an adequate amount of material is available to properly fill a dosage form
  • Acting as an antimicrobial or antioxidant to extend the shelf life of the active ingredient
Thus, the definition of pharmaceutical additives for the purpose of this work encompasses excipients, synergists, or chemicals that substantively contribute to the effectiveness of the active ingredient. Entries for both trade names and chemicals contain extensive information gathered from worldwide manufacturers, distributors, trade journals, government documents, and other reference sources.

Target information on components by:
Trade Name ? Chemical Name ? Synonym ? Function ? Application ? CAS Number ? EINECS Number ? FEMA Number ? Manufacturer

Coverage includes Pharmaceutical Additive chemicals that function as:
Absorbents/Adsorbents ? Acidulents/Buffer/pH adjuster/Neutralizers ? Aerosols/Propellants ? Anticaking agents Anticoagulants ? Antigellant ? Anti-inflammatory agents/Antiphlogistic agents ? Antimicrobials ? Antioxidants ? Astringents ? Bases ? Chelating agent/Sequestrants ? Coagulants ? Coating agents ? Colorant/Color enhancers/Dyes/Pigments ? Complexing agent ? Conditioners ? Controlled release agent ? Crystal growth Regulators ? Denaturants ? Dessicant/Drying agents/Dehydrating agents ? Dietary Supplements ? Dispersants ? Emollients ? Emulsifiers ? Encapsulants ? Enzymes ? Fillers/Extenders/Diluents/Excipients ? Flavor/Flavor enhancers ? Flow aids ? Fragrances/Perfumes/Aromatics ? Gellants ? Hardeners/Stiffeners ? Humectants Lubricants ? Moisturizer ? Nutritive fortifiers ? Odor masking agents ? Opacifiers ? Permeation enhancers ? Plasticizers ? Protective agents/Soothing agents/Demulcents ? Solvents ? Spreading agents ? Stabilizers ? Superfatting agents Sweeteners ? Synergists ? Tablet binders ? Tablet disintegrants ? Tabletting aids ? Tonicity agents ? UV absorbers ? Vehicles/Carriers ? Viscosity modifier ? Water repellants ? Wetting agents

In these Application Areas:
Orals:Tablets, Capsules, Syrups/Liquids/Suspensions Topicals: Ointments/Creams/Lotions/Gels Suppositories ? Ophthalmics ? Otics ? Injectables ? Inhalants
Content

PART I-Trade Name Reference

Trade Name Reference contains over 4200 alphabetical entries of trade name pharmaceutical additive products with extensive profiles of each product listed.


PART I-Trade Name Reference

Trade Name Reference contains over 4200 alphabetical entries of trade name pharmaceutical additive products with extensive profiles of each product listed.


Part II-Chemical Component Cross-Reference

Chemical Component Cross-Reference contains almost 3300 pharmaceutical chemicals/materials that are either contained in the trade name products profiled in Part I or are generic chemicals used as pharmaceutical additive ingredients. Each entry includes, wherever possible, its synonyms, CAS number, EINECS number/ELINCS, FEMA number, UN/DOT number, molecular and empirical formulas, chemical properties, functions and applications, toxicology, precautions, use levels, regulatory information, and manufacturers and distributors of the chemical. All chemical/material synonyms are cross-referenced back to the main entry. The chemical monograph entries also contain a listing of the trade name products that are either equivalent to the chemical entry or contain this chemical as one of its ingredients.

Part III-Functional/Application Index


Functional/Application Index is a powerful tool for locating the trade names and chemicals based on their function and application. By searching for key functional words related to pharmaceutical additives such as anticaking agents, binders, colorants, disintegrants, emulsifiers, encapsulants, fillers, flavors, gellants, in specific application areas such as tablets, capsules, inhalants, ointments, suppositories, etc., the user is directed to the trade names and/or chemicals that have that specific functional/application attribute. The generic component names are distinguished from the trade names by italic type in the book and color in the software.

Part IV-Manufacturers Directory

Detailed contact information for the more than 2000 worldwide manufacturers and their branches of trade name products and chemical components that are referenced in this handbook. Wherever possible, telephone, telefax, toll-free numbers, e-mail and internet addresses (functional in the software), and complete mailing addresses are included for each manufacturer.The drive towards globalisation

Additional Indexes

CAS Number Index contains CAS number entries followed by a listing of their trade name product and chemical equivalents in alphabetical order. The chemical name is in boldfaced type.

EINECS/ELINCS Number Index contains EINECS/ELINCS number entries followed by a listing of their trade name product and generic chemical equivalents in alphabetical order. The chemical name is in boldfaced type.

FEMA Number Index orders chemicals contained in this reference by these numbers (assigned by the Flavor and Extract Manufacturers Association).

Glossary contains definitions of terminology associated with pharmaceutical additives and their application areas.

Since 1981, Michael & Irene Ash have maintained a trade name and chemical database that is continuously updated by gathering information from chemical manufacturers, researching chemicals in reference books and databases, and investigating new products and companies in numerous industrial and chemical trade journals. The authors put the collected material then put through a rigorous filtering process that results in the uniform storage of product data so that the comparison of information from the multitude of chemical manufacturers worldwide is made accessible through carefully designed reference books.